Knowledge
Technical notes and reference articles on molecular interpretation, tumor board organisation and drug safety. They are written for clinical professionals and health technology teams, with general information and identified sources.
Molecular interpretation
The AMP/ASCO/CAP framework and the ESMO ESCAT scale rank the clinical relevance of variants detected in an NGS panel. We review what each one measures, how their evidence levels are structured and why the same variant can be classified differently depending on the tumour context.
8 min read
Clinical practice
Most molecular board sessions stall over missing data, not over a lack of judgement. We review the minimum set of information worth preparing and why each element changes the interpretation of the same molecular profile.
8 min read
Drug safety
Many oral targeted therapies are metabolised through CYP3A4 and some are associated with QT interval prolongation. We review the mechanisms, where to consult authoritative information and how to document the review of concomitant medication.
9 min read
The content in this section is general information and does not constitute medical advice or a treatment recommendation.
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